Serum concentrations of modafinil could possibly be diminished into a clinically major extent during the presence of medications that induce CYP3A4. These include things like rifampin, phenytoin, St John Wort, and efavirenz.These lifestyle-threatening rashes connected with modafinil seem exceptionally rare, although the specific incidence premiums
Bettendorf et al (1996) utilized substantial performance liquid chromatography to study cortical glutamate and GABA levels of sacrificed rats just after modafinil-induced paradoxical snooze deprivation and non-pharmacological paradoxical slumber deprivation utilizing the System technique, where the paralysis of REM slumber triggers rats to generate
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